Research Explorer Ruhr: Hosts and Application

Natural and Life Sciences

Here you find the profiles of the participating professors. You can conveniently apply directly at the end of each profile: please fill in the application form and send it to us via the green button at the end of the document.

Biology

Prof. Dr. Thomas Happe (Ruhr-Universität Bochum)

Biology and Biotechnology

Photobiotechnology

Research Area

The working group deals with the basic questions of the biochemistry, genetic and biotechnology of photosynthetic microorganism. Microorganism that practice an oxygenic photosynthesis are able to metabolize hydrogen under certain conditions. In cyanobacteria the development of hydrogen is strongly coupled to nitrogen fixation, while green algae that possess no nitrogenase produce hydrogen in mentionable amounts only under photosynthetic conditions. Interestingly, two different classes of H2-producing enzymes are found in cyanobacteria (NiFe-hydrogenases) and green algae (Fe-hydrogenases) which indicate a different phylogenetic origin. The enzymes that are involved in the hydrogen metabolism and nitrogen fixation are extremely oxygen sensitive so that the expression of the proteins takes place only under anaerobic conditions.
The aim of our research is to understand the coaction of different metabolic pathways (photosynthesis, sulphur metabolism, nitrogen fixation and hydrogen production) in the photosynthetic cyanobacteria and green algae.

Candidate Profile

I am open to every candidate (biologist, chemist, biophysicist ) who is really interested in the research of my group.

Host Website: Link

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Chemistry and Biochemistry

Prof. Dr. Lukas Gooßen (Ruhr Universität Bochum)

Evonic Chair of Organic Chemistry

 

Research Area

The research in the Gooßen group is devoted to the development of sustainable transition metal-catalyzed reactions as alternatives to waste-intensive multi-step transformations.

Primary research goals are

- inventing new chemical reactions based on mechanistic considerations
- devising concepts for the selective functionalization of C-C and C-H bonds
- enabling the use of alternative substrates that have inherent advantages with regard to the reduction of salt waste, e.g. carboxylic acids, alcohols, amines
- developing reagents and reactions for late stage fluoroalkylations
- implementig new concepts for the valorization of renewables and of CO2
- gaining an in-depth mechanistic understanding of catalytic reactions with a focus on solvent effects

Candidate Profile

If you …

- love chemistry as much as we do
- want to do exciting and challenging research at a top international level
- are a skillful chemist full of new ideas
- have good knowledge of English
- are not afraid of computers and laboratory automation
- have a solid understanding of organometallic chemistry
- and feel the desire to go beyond the paved paths of synthesis and catalysis
... you might be just the right person for us.

Qualifications: PhD in Chemistry; good grades and publication record proving chemical understanding and creativity

Host Website: Link

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Prof. Dr. Thomas Günther-Pomorski (Ruhr Universität Bochum)

Molecular Biochemistry

 

Research Area

A fundamental feature of eukaryotic cells is their compartmentalization into distinct organelles by biological membranes. Each membrane is composed of thousands of interacting lipids and proteins that are essential to basic processes from photosynthesis to the maintenance of electrochemical gradients across membranes. Many membrane proteins, including pumps and transporters, form multimeric complexes that can vary and adapt to the functional state of the cell.
We are interested in revealing organization, functioning and dynamics of membrane pumps and their complexes. To this end, we have developed a variety of biochemical, biophysical and microscopic techniques including the synthesis of specific lipid probes for characterizing membrane properties, protein-membrane interactions and lipid trafficking in fungi, parasites and mammalian cells. Detailed insight into the molecular functioning of membrane pumps will help to understand vital processes at cellular membranes and pave the way for applications within synthetic biology such as personal medicine, sustainable energy production, and molecular bioelectronics.

Candidate Profile

We would like to support candidates who have or will soon complete a doctoral degree in cell biology, molecular biology, biochemistry, biophysics or related areas and are interested to work on lipid transporters. Competence in molecular techniques, protein biochemistry or cell biology are important. A strong expertise in protein purification and reconstitution would be a further asset. Additionally, we are seeking for candidates with a strong expertise in Leishmania parasite cell culture and biology or confocal microscopy techniques. We expect very good English skills, team spirit and the ability of working independently.

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Mathematics

Prof. Dr. Deniz Kus (Ruhr-Universität Bochum)

Mathematics

Algebra and Geometry

Research Area

My research interests are all sort of representation theory and algebraic combinatorics. I have strong side interests in the interaction between representation theory, number theory, basic hypergeometric series, geometry and combinatorics. Our group is currently focussed on classifying the regular subalgebras of extended affine Lie algebras of nullity 2 and the candidate should be involved in ongoing projects.

Candidate Profile

We are looking forward to host a motivated and independently working scientist, who is interested in the field of representation theory and holds a master degree in mathematics; favourably close to completing a doctoral degree. Knowledge in algebraic Lie theory or algebraic geometry would be an additional advantage.

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Medicine

Prof. Dr. Ralf Erdmann (Ruhr-Universität Bochum)

Institute of Biochemistry and Pathobiochemistry

System Biochemistry

Research Area

The research area of the Erdmann group is Molecular Cell Biology and the major research interests concern the biogenesis and function of cellular organelles with emphasis on the topogenesis of proteins.
The Erdmann group has special interest in the biogenesis of peroxisomes and lipid droplets. The group focusses on the elucidation of peroxisomal protein import, proliferation of peroxisomes, the molecular basis for peroxisome biogenesis disorders, assembly of lipid droplets as well as the assessment of glycosomes as molecular target for trypanosomal diseases.

The main aim of this project is to extend the scope of using inhibitors as potential therapy against trypanosomal diseases. Here we will specifically focus on :
a. Identification of novel peroxisome inhibitors using in vitro assays
b. Identification of inhibitors with anti-trypanosomal activity using in vivo assays
c. Validation of the on-target action of inhibitors
d. Development of a phenotypic assay for screening of new glycosome biogenesis inhibitors in T. cruzi

Candidate Profile

The candidate should have a Master Degree in Life Science.

He/She should
- be a highly motivated team player
- be able to perform experiments on his/her own
- be able to plan and carrying out the tasks assigned to him/her independently
- be able to assist guiding others including students.
- be very creative that is expressed in creative plans, original ideas, etc.
- have convincing expertise in biochemistry and molecular cell biology
- be eager to aquire knowledge in the entire field in which they are involved.
- be curious and devoted to his/her scientific projects

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Prof. Dr. Konstanze F. Winklhofer (Ruhr-Universität Bochum)

Institute of Biochemistry and Pathobiochemistry

Molecular Cell Biology

Research Area

Our research interest is focused on stress response and quality control pathways that are essential to maintain cellular homeostasis and organellar integrity. A decreased efficiency of these pathways is associated with aging and can lead to age-related pathologies, such as neurodegenerative diseases. In this context, a major focus of our work are the causes and consequences of protein misfolding and the role of mitochondria as key organelles in orchestrating cell death and viability and regulating cellular bioenergetics.

Specifically, our ongoing and planned projects concentrate on the following aspects:
1. Ubiquitin signaling at the interface between stress protection and immune responses
2. Pathways maintaining mitochondrial integrity
3. The role of interorganellar crosstalk in the cellular stress response
4. Cellular quality control pathways to prevent proteotoxic stress

To address the following questions, we are using approaches combining cell biology, molecular biology, biochemistry and imaging techniques including superresolution imaging, life cell imaging, and confocal laser scanning microscopy.

Candidate Profile

We are looking for a highly motivated and dedicated candidate, willing to work in a team of international coworkers. The successful candidate will hold a PhD in biochemistry, biology, molecular biology, genetics, or a related field. She/he should have a strong scientific track record of accomplishments and proven research capabilities. Beside creativity we expect excellent communication and organizational skills, fluency in English, and a strong team spirit. Experience in working with cellular model systems and cellular imaging techniques is desirable.

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Physics

Prof. Dr. Michael Farle (University of Duisburg-Essen)

Experimental Physik

AG Farle

Research Area

The group “Structure and Magnetism of Nanoscaled systems” at the University of Duisburg-Essen investigates magnetic nanostructures , low-dimensional spin-hybrid systems and recently also bulk magnets. The interests focus on the understanding of the correlation of morphology, crystal structure and magnetism.

Candidate Profile

Expertise in materials science
Experience in XRD and TEM , materials synthesis and/or magnetic materials

Host Website: Link

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